demonstrated that nucleases restrain the development of
preparations of pathogenic viruses. The main mechanism of
such antiviral action is the destruction of the bonds of
viral nucleotides denaturalizing such viruses, destroying
the genetic information and their infective characteristics.
This action takes place when viruses lose their protective
protein coat, after having entered the cell in the living
macro-organism. There are circumstances where nucleases
penetrate the hematoencephalic barrier, they have very low
toxicity, they do not interfere with respiration, nor with
arterial blood pressure, nor with the tone of involuntary
muscles and they also do not have any toxic action over the
central nervous system.
According to the microstructure of the viruses, RNAse is
used in those cases of illness caused by viruses which
contain ribonucleic acid, such as the viruses of parotiditis,
laryngitis, encephalitis, meningytis, broncheolitis, equine
encephalitis, enterovirus and viruses that cause liver,
ovaric, of the upper respiratory via, mammal and pancreatic
cancer, and even the rabies virus.
is used for the treatment of illnesses caused by viruses
that contain deoxirribunuclease acid, such as adenovirus,
the herpes viruses, of chicken pox and of some neuritis of
viral origin. It has been determined that herpes zoster is
also sensible to DNAse. Its application caused a quick
reduction of the pain; and the hyperesthesia as well as
dermic rash ceased. In the treatment of progressive
sclerosis, the best results where obtained in those cases of
mild and premature forms.
Nucleases have also been used in the treatment of acute
brainspinal polyradyculo neuritis of Guillan-Barre-Landry,
of brainspinal radyculoganglonitis and sympathic nodes of
herpetic ethiology. DNAse restrained the development of
symptoms of herpetic viral polyradyculoneuritis and in short
period attained its complete remission.
studies pertaining to oncological problems of viral origin a
low concentration of local nucleases has been detected,
which has been interpreted as a depletion of them or an
increase in the specific inhibiting agent present in cells.
However, in other cases of viral infection at the seric
level of nucleases is found to be high, which is interpreted
as a deficiency of its excertion, it is worth pointing out
that the best results have been obtained to significantly
reduce metastatic dissemination. Most cancer patients
treated with the combination of RNAsa and DNAse present an
improvement of their general condition, pain relief,
decrease of the timorous mass and frequently, the
prolongation of their life. It has to be pointed out that
this association does not present secondary effects, very
different to those caused by other chemotherapies.
been observed that a relevant trait of the action of
nucleases is that several antibiotics increase significantly
their sensitivity over pathogenic microbes and even
Dosification of this product corresponds to the age of the
patient, his weight and the seriousness of the illness: from
1 to 5 ml. by intramuscular application every 12, 24 or 72
hours, to 25 ml. dissolved in 250 ml. of isotonic solution
of sodium chloride every 12 to 72 hours.
ml twice a week via intramuscular to 5 ml daily for a 60 kg.
adult, depending on the disease's seriousness.